Stokes trap: flow-based manipulation of particles and molecules
Our group developed the Stokes trap, which is a new method for trapping and manipulating small particles using only fluid flow. The ability to confine single particles and molecules has revolutionized several fields of science, with common methods including optical traps and magnetic tweezers. Automated flow control offers an attractive method for particle manipulation without the need for optical, electric, acoustic, or magnetic fields. The Stokes trap allows for precise control over the center-of-mass position, orientation, and trajectories for multiple particles using only fluid flow. We are using this technique for the fluidic-directed assembly of particles in solution, and we are further studying the dynamics of soft materials such as lipid vesicles, polymersomes, and collision and adhesion events for membrane-bound vesicles. From a broad perspective, this technique opens new vistas for fundamental studies of particle-particle interactions and provides a new method for the directed assembly of colloidal particles.
1. Dinesh Kumar, Anish Shenoy, Songsong Li, and Charles Schroeder, “Orientation control and nonlinear trajectory tracking of colloidal particles using microfluidics”, Physical Review Fluids, 4, 114203 (2019).
2. Anish Shenoy, Dinesh Kumar, Sascha Hilgenfeldt, and Charles Schroeder, “Flow topology during multiplexed particle manipulation using a Stokes trap”, Physical Review Applied, 12, 054010 (2019).
3. Anish Shenoy, Christopher Rao, and Charles Schroeder, “Stokes trap for multiplexed particle manipulation and assembly using fluidics”. Proceedings of the National Academy of Sciences, 113, 3976-3981 (2016).
4. Dinesh Kumar, Anish Shenoy, Jonathan Deutsch, and Charles Schroeder, “Automation and flow control for particle manipulation”, Current Opinion in Chemical Engineering, 29, 1-8, (2020).
5. M. Tanyeri and C. M. Schroeder, “Manipulation and Confinement of Single Particles using Fluid Flow”, Nano Letters, 13, 2357 (2013).
6. M. Tanyeri, M. Ranka, N. Sittipolkul, C. M. Schroeder, “A Microfluidic-based Hydrodynamic Trap: Design and Implementation”, Lab on a Chip, 11, 1786 (2011).